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Cannabidiol (CBD) oil is a natural compound used for many common ailments. Cannabidiol is derived from the hemp plant and contains 0.3% THC. While THC is the active ingredient in marijuana known for its euphoric, ‘high’ effects, CBD is a phytocannabinoid that is non-psychotoxic. With only 0.3% THC in PlusCBD Oil, this minute amount does not result in a euphoric, ‘high’ feeling.
Benefits of CBD
  1. Helps Relieve Pain
  • The human body contains a specialized system called the endocannabinoid system (ECS). This system is responsible for regulating a variety of functions ranging from sleep, appetite, pain responses and immune function. The body naturally produces endocannabinoids, which are neurotransmitters that bind to specific receptors in the ECS. Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters. (1)
  • In a study of 47 people with Multiple Sclerosis, those treated with CBD oil for 1 month experienced a significant improvement in pain, walking and muscle spasms. (2)
  • In a study of 58 people with Rheumatoid Arthritis, those treated with CBD & THC oil significantly improved pain during movement, pain at rest and sleep quality. (3)
 2.  Reduce Anxiety and Depression
  • Depression is the #1 largest contributor to disability worldwide while anxiety disorders rank 6th. CBD acts on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior. In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test. The group that received CBD had significantly less anxiety, cognitive impairment and discomfort in their speech performance compared to placebo group. (4)
  • CBD oil has also been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder (PTSD) (5)
 3.  Alleviate Cancer-Related Symptoms
  • CBD helps reduce symptoms related to cancer and side effects such as nausea, vomiting and pain. (6)
  • Some test-tube studies have shown CBD to have anti-cancer properties. One test-tube study found that concentrated CBD induced cell death in human breast cancer cells. (7)
 4.  Reduce Acne
  • Acne is a skin condition affecting 9% of the population and is thought to be caused by factors such as genetics, bacteria, underlying inflammation and overproduction of sebum. CBD oil may help treat acne due to its anti-inflammatory properties and ability to reduce sebum production. (8)
 5.  Neuroprotective Properties
  • CBDs ability to act on the ECS and other signaling systems of the brain can provide benefits for those with neurological disorders. A study involving 214 people with severe epilepsy were given 0.9-2.3 grams of CBD oil per pound of body weight. Their seizures reduced by a median of 36.5%! (9)
  • Treatment with CBD has been shown to improve quality of life and quality of sleep for people with Parkinson’s disease. (10)
 6.  Benefit Heart Health
  • CBD has been linked with several benefits for the heart and circulatory system, including the ability to lower high blood pressure. One study treated 10 healthy men by administering 600 mg of CBD oil and found reduced resting blood pressure as well as smaller blood pressure increases in response to stress tests. (11)
Side Effects of CBD
CBD is generally well-tolerated and considered safe, however it may cause adverse reactions for some people. Side effects noted in studies include:
  • Anxiety and depression
  • Psychosis
  • Nausea, vomiting and diarrhea
  • Drowsiness
  • Dry mouth
  • Dizziness
  • Changes in appetite.
CBD can also interact with several medications. If you are taking any prescriptions medications, please discuss with your doctor to ensure safety and avoid harmful interactions prior to taking CBD.
  1. Deer, T.R. et al., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches, American Academy of Pain Medicine 2013
  2. Russo et al., Sativex in the Management of Multiple Sclerosis-related Spasticity: Role of the Corticospinal Modulation, Neural Plasticity 2015 Jan 29
  3. Blake, D.R. et al., Preliminary Assessment of the Efficacy, Tolerability and Safety of a Cannabis-based Medicine (Sativex) in the Treatment of Pain caused by Rheumatoid Arthritis, British Society for Rheumatology, 2006 Jan
  4. Bergamaschi, M. et al., Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients, Neuropsychopharmacology 2011 May
  5. Shannon, S, Opila-Lehman, J, Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report, Permanente Journal, 2016 Fall
  6. Bloechi-Daum, B et al., Delayed Nausea and Vomiting Continue to Reduce Patients’ Quality of Life after Highly and Moderately Emetogenic Chemotherapy Despite Antiemetic Treatment, Journal of Clinical Oncology 2006 Sep 20
  7. Shrivastava, A. et al., Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-Talk Between Apoptosis and Autophagy, Molecular Cancer Therapeutics 2011 July
  8. Olah, A. et al., Cannabidiol Exerts Sebostatic and Antiinflammatory Effects of Human Sebocytes, Journal of Clinical Investigation 2014 Sep 2
  9. Devinsky, O. et al., Cannabidiol in Patients with Treatment-resistant Epilepsy: An Open-Label Interventional Trial, Lancet Neurology 2016 Mar
  10. Chagas M.H. et al., Cannabidiol Can Improve Complex Sleep-related Behaviors Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease Patients: A Case Series, Journal of Clinical Pharmacy and Therapeutics 2014 Oct
  11. Jadoon, K.A. et al., A Single Dose of Cannabidiol Reduces Blood Pressure in Healthy Volunteers in a Randomized Crossover Study, American Society for Clinical Investigation 2017 Jun 15
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